Issa Dee and Molly Carter’s was one the most relatable onscreen friendships audiences had seen in a while. Portrayed by actresses Issa Rae and Yvonne Orji, the duo navigated the challenges of life, love, and career in Los Angeles. Their friendship was central to the show, and viewers were heartbroken when they experienced a brief falling out. Fortunately, their estrangement was short-lived, and they stayed close friends until the end, highlighting the complexities and beauty of long-term friendships. The real-life friendship between Rae and Orji also added an extra layer of warmth to their on-screen relationship.

Joan, Maya, Lynn, and Toni, played by the ensemble cast of Tracee Ellis Ross, Golden Brooks, Persia White, and Jill Marie Jones, respectively, are the epitome of squad goals, ups and downs included. This iconic series delved into the lives of four women as they support each other through personal and professional challenges while living in L.A.  

In “Set It Off,” Cleo, Stony, T.T., and Frankie, portrayed by actresses Queen Latifah, Jada Pinkett Smith, Vivica A. Fox, and Kimberly Elise, respectively, share a tight-knit friendship that's built on their shared struggles and experiences. They face financial hardships and systemic injustices together, but they always have each other's backs no matter what. Their bond is strong and unbreakable, showing just how powerful their sisterhood is as they navigate life's challenges side by side.

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On “Living Single,” the friendship between Synclaire, Maxine, Khadijah, and Regine was one for the ages. Synclaire, played by Kim Coles, is the quirky and lovable one who always keeps things light. Maxine, brought to life by Erika Alexander, is the sharp and witty lawyer who's fiercely loyal. Queen Latifah’s Khadijah is the ambitious magazine editor who keeps everyone grounded, while Kim Fields’ Regine adds her own flair with her high standards and fashion-forward style. Together, they tackle life's ups and downs in New York City, creating a bond that's both heartwarming and hilarious.

Pam and Gina from Martin are a quintessential example of best friends. Pam, played by Tichina Arnold, and Gina, played by Tisha Campbell, are dynamic, strong-willed women who often clash but remain loyal to each other through thick and thin. Their friendship is marked by playful banter, mutual support, and genuine care, making them one of TV’s most memorable pairs.

Sicily and Kyla Pratt’s portrayal of Spirit and Breanna’s friendship is truly iconic for its blend of humor, support, and authenticity. Watching them navigate the ups and downs of school and life together was not just entertaining but also a great reminder of how true friends support each other through everything.

Despite their diverse personalities and backgrounds, Jaleesa (Dawnn Lewis), Kimberly (Charnele Brown), Freddie (Cree Summer), Whitley (Jasmine Guy), and briefly, Denise (Lisa Bonet) consistently rallied behind one another. Whether advocating for a cause or simply being there for each other, their unwavering support and camaraderie made their relationships truly special.