Them Simmons boys ain’t nothing to play with.

Obviously taking cues from his father Rev. Run and little brother Diggy, JoJo Simmons is not one to back down from a rap battle. In response to Juelz Santana mentioning his name on the mixtape banger "Soft," JoJo unleashed scathing diss freestyle "Holy Water" yesterday [Jan. 31].

On the Rick Ross-assisted track from his latest mixtape, God Will'n, the Dipset member rapped, "As far as that dough goes/ I’m Russell Simmons, you JoJo."

The line prompted Rev. Run’s eldest son to hop in the booth and record a vicious response.

"Now how you gonna mention my uncle Russell / Then disrespect his nephew / The industry forgot you / f------, you nothing special," JoJo griped. "Why you have to call my name / Thought you retired / Boy, that little bit of fame you had / That s--t had died / Tryna ride Ross' d--k to get a hit, you high."

This is not the first time a young Simmons has went on the attack after feeling slighted. Diggy Simmons also defended the Simmons family name last year on "What You Say to Me" after J. Cole name-dropped him on "Grew Up Fast" in addition to allegedly rapping about his older sister, Vanessa Simmons, on "Purple Rain."

Rappers beware: keep the Simmons name out your raps, or else.

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(Photos from left: John Ricard / BET, Jemal Countess/Getty Images)