While no one is certain of exactly how The Oprah Winfrey Show will end, plenty of people are guessing. According to the rumor mill, the finale will be a two-part episode taped on May 17 at the United Center. The show will pay “homage to the Queen of TV and her 25-year career.”

The first hour will apparently be hosted by Tom Hanks, while Will Smith will helm the second hour. There will be even more celebrity appearances from the likes of Tom Cruise, Hugh Jackman, Jamie Foxx, Jerry Seinfield and her good friend, Tyler Perry. Musical guests are said to include Beyoncé, Jay-Z, Usher, Patti LaBelle, Rihanna and Mary J. Blige.

As of now, Oprah and her team have revealed no official details about the finale, other than its air date: May 25, 2011.

(Photo: George Burns/Harpo, Inc./Landov)